| 6. Ronde | 31.07.2022 | Santos Laguna [U20] | - | Atlas Guadalajara [U20] | 1:1 | ||||
| 1. Ronde | 03.08.2022 | Santos Laguna [U20] | - | CF Monterrey [U20] | 2:1 | ||||
| 7. Ronde | 06.08.2022 | Santos Laguna [U20] | - | Cruz Azul [U20] | 2:1 | ||||
| 8. Ronde | 14.08.2022 | UANL Tigres [U20] | - | Santos Laguna [U20] | 2:2 | ||||
| 9. Ronde | 18.08.2022 | Santos Laguna [U20] | - | Club León [U20] | 2:3 | ||||
| 10. Ronde | 21.08.2022 | Pumas UNAM [U20] | - | Santos Laguna [U20] | 0:1 | ||||
| 16. Ronde | 26.08.2022 | Club Tijuana [U20] | - | Santos Laguna [U20] | 1:1 | ||||
| 11. Ronde | 28.08.2022 | Santos Laguna [U20] | - | Atlético San Luis [U20] | 7:2 |  |
|||
| 12. Ronde | 03.09.2022 | CF Pachuca [U20] | - | Santos Laguna [U20] | 5:1 | ||||
| 13. Ronde | 06.09.2022 | Santos Laguna [U20] | - | Club Necaxa [U20] | 3:2 | ||||
| 14. Ronde | 10.09.2022 | Gallos Blancos [U20] | - | Santos Laguna [U20] | 2:2 | ||||
| 5. Ronde | 14.09.2022 | CF América [U20] | - | Santos Laguna [U20] | 1:0 | ||||
| 15. Ronde | 18.09.2022 | Santos Laguna [U20] | - | FC Juárez [U20] | 3:0 | ||||
| 17. Ronde | 02.10.2022 | Santos Laguna [U20] | - | Mazatlán FC [U20] | 2:3 |
Mexico