| 3. Ronde | 05.08.2021 | Gallos Blancos [U20] | - | Club León [U20] | 1:0 | ||||
| 4. Ronde | 14.08.2021 | Club León [U20] | - | Mazatlán FC [U20] | 1:0 | ||||
| 5. Ronde | 18.08.2021 | Deportivo Guadalajara [U20] | - | Club León [U20] | 1:2 | ||||
| 6. Ronde | 21.08.2021 | Club León [U20] | - | Santos Laguna [U20] | 1:1 |  |
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| 9. Ronde | 18.09.2021 | Club León [U20] | - | FC Juárez [U20] | 2:0 | ||||
| 10. Ronde | 25.09.2021 | Atlas Guadalajara [U20] | - | Club León [U20] | 2:1 | ||||
| 13. Ronde | 16.10.2021 | CF Monterrey [U20] | - | Club León [U20] | 1:1 | ||||
| 14. Ronde | 20.10.2021 | Club León [U20] | - | Pumas UNAM [U20] | 0:2 | ||||
| 16. Ronde | 31.10.2021 | Deportivo Toluca [U20] | - | Club León [U20] | 1:0 | ||||
| 11. Ronde | 03.11.2021 | Cruz Azul [U20] | - | Club León [U20] | 2:0 |
Mexico