| 1. Ronde | 08.01.2023 | Santos Laguna [U20] | - | UANL Tigres [U20] | 0:1 |  |
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| 2. Ronde | 14.01.2023 | Santos Laguna [U20] | - | Pumas UNAM [U20] | 1:6 | ||||
| 3. Ronde | 20.01.2023 | Mazatlán FC [U20] | - | Santos Laguna [U20] | 2:3 | ||||
| 5. Ronde | 04.02.2023 | Santos Laguna [U20] | - | CF América [U20] | 0:1 | ||||
| 6. Ronde | 10.02.2023 | FC Juárez [U20] | - | Santos Laguna [U20] | 1:0 | ||||
| 8. Ronde | 18.02.2023 | Atlético San Luis [U20] | - | Santos Laguna [U20] | 0:1 | |
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| 10. Ronde | 04.03.2023 | Deportivo Guadalajara [U20] | - | Santos Laguna [U20] | 1:0 | |
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| 11. Ronde | 12.03.2023 | Santos Laguna [U20] | - | Club Tijuana [U20] | 1:3 | ||||
| 12. Ronde | 19.03.2023 | Club León [U20] | - | Santos Laguna [U20] | 1:3 | ||||
| 13. Ronde | 31.03.2023 | Club Necaxa [U20] | - | Santos Laguna [U20] | 0:2 | ||||
| 14. Ronde | 09.04.2023 | Santos Laguna [U20] | - | CF Pachuca [U20] | 1:3 | ||||
| 7. Ronde | 19.04.2023 | Santos Laguna [U20] | - | Deportivo Toluca [U20] | 2:1 | ||||
| 17. Ronde | 29.04.2023 | Cruz Azul [U20] | - | Santos Laguna [U20] | 2:1 | |
Mexico