| 3. Ronde | 21.08.2021 | FC Penafiel | - | Casa Pia AC | 1:0 | ||||
| 5. Ronde | 12.09.2021 | FC Penafiel | - | CD Nacional | 1:0 | ||||
| 9. Ronde | 23.10.2021 | FC Penafiel | - | Rio Ave FC | 1:1 | ||||
| 13. Ronde | 05.12.2021 | FC Penafiel | - | Académica de Coimbra | 0:0 |  |
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| 14. Ronde | 11.12.2021 | CD Feirense | - | FC Penafiel | 1:2 | |
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| 15. Ronde | 19.12.2021 | FC Penafiel | - | Estrela Amadora | 0:2 | ||||
| 16. Ronde | 23.12.2021 | FC Porto B | - | FC Penafiel | 3:1 | ||||
| 18. Ronde | 15.01.2022 | FC Penafiel | - | UD Vilafranquense | 4:3 | ||||
| 20. Ronde | 31.01.2022 | Casa Pia AC | - | FC Penafiel | 2:0 | |
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| 21. Ronde | 07.02.2022 | FC Penafiel | - | CD Trofense | 1:0 | ||||
| 25. Ronde | 06.03.2022 | FC Penafiel | - | GD Chaves | 2:1 | ||||
| 26. Ronde | 12.03.2022 | Rio Ave FC | - | FC Penafiel | 2:0 | ||||
| 27. Ronde | 19.03.2022 | FC Penafiel | - | SC Farense | 1:3 | ||||
| 28. Ronde | 01.04.2022 | Leixões SC | - | FC Penafiel | 0:1 | ||||
| 29. Ronde | 08.04.2022 | FC Penafiel | - | Varzim SC | 4:1 | ||||
| 30. Ronde | 16.04.2022 | Académica de Coimbra | - | FC Penafiel | 0:0 | |
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| 31. Ronde | 24.04.2022 | FC Penafiel | - | CD Feirense | 2:0 | |
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| 33. Ronde | 07.05.2022 | FC Penafiel | - | FC Porto B | 1:2 |  |
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| 34. Ronde | 13.05.2022 | Académico de Viseu | - | FC Penafiel | 1:2 |
Portugal