| 19. Ronde | 05.09.2021 | Deportes Iquique | - | Barnechea | 4:2 | ||||
| 20. Ronde | 16.09.2021 | San Luis | - | Deportes Iquique | 1:1 |  |
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| 21. Ronde | 23.09.2021 | Deportes Iquique | - | Deportes Copiapó | 2:1 | ||||
| 22. Ronde | 27.09.2021 | CD Magallanes | - | Deportes Iquique | 2:2 | ||||
| 23. Ronde | 03.10.2021 | Deportes Iquique | - | Santa Cruz | 6:1 | ||||
| 24. Ronde | 08.10.2021 | Universidad de Concepción | - | Deportes Iquique | 3:1 | ||||
| 25. Ronde | 13.10.2021 | Deportes Iquique | - | Cobreloa | 1:0 | ||||
| 26. Ronde | 20.10.2021 | Deportes Iquique | - | Unión San Felipe | 1:0 | ||||
| 27. Ronde | 25.10.2021 | Santiago Morning | - | Deportes Iquique | 1:0 | ||||
| 28. Ronde | 01.11.2021 | Deportes Iquique | - | Rangers | 2:2 | ||||
| 29. Ronde | 06.11.2021 | Deportes Temuco | - | Deportes Iquique | 2:1 | ||||
| 30. Ronde | 13.11.2021 | Deportes Iquique | - | Puerto Montt | 4:2 |
Chili