| 5. Ronde | 11.09.2021 | GD Estoril [A-jun] | - | CD Nacional [A-jun] | 1:1 |  |
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| 8. Ronde | 03.10.2021 | CD Nacional [A-jun] | - | FC Alverca [A-jun] | 3:1 |  |
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| 2. Ronde | 09.10.2021 | CD Nacional [A-jun] | - | UD Vilafranquense [A-jun] | 1:1 | ||||
| 9. Ronde | 16.10.2021 | Amora FC [A-jun] | - | CD Nacional [A-jun] | 1:1 | ||||
| 10. Ronde | 23.10.2021 | União Leiria [A-jun] | - | CD Nacional [A-jun] | 1:0 | ||||
| 4. Ronde | 27.10.2021 | CD Nacional [A-jun] | - | SG Sacavenense [A-jun] | 2:1 | ||||
| 11. Ronde | 31.10.2021 | CD Nacional [A-jun] | - | SL Benfica [A-jun] | 0:6 | ||||
| 19. Ronde | 08.01.2022 | FC Alverca [A-jun] | - | CD Nacional [A-jun] | 3:1 | ||||
| 14. Ronde | 11.01.2022 | CD Nacional [A-jun] | - | Académica de Coimbra [A-jun] | 3:2 |
Portugal