| 2. Ronde | 01.08.2021 | Santos Laguna [U18] | - | Cruz Azul [U18] | 1:2 | ||||
| 3. Ronde | 07.08.2021 | UANL Tigres [U18] | - | Santos Laguna [U18] | 0:0 | ||||
| 6. Ronde | 21.08.2021 | Club León [U18] | - | Santos Laguna [U18] | 3:1 | ||||
| 7. Ronde | 29.08.2021 | Santos Laguna [U18] | - | FC Juárez [U18] | 0:0 | ||||
| 8. Ronde | 10.09.2021 | Club Tijuana [U18] | - | Santos Laguna [U18] | 3:0 | ||||
| 14. Ronde | 15.09.2021 | CF América [U18] | - | Santos Laguna [U18] | 0:1 | ||||
| 9. Ronde | 19.09.2021 | Santos Laguna [U18] | - | Puebla FC [U18] | 5:1 | ||||
| 10. Ronde | 26.09.2021 | Santos Laguna [U18] | - | CF Monterrey [U18] | 2:0 |
Mexico