| 1. Ronde | 07.08.2021 | GD Estoril [A-jun] | - | Vitória Setúbal [A-jun] | 2:2 | ||||
| 3. Ronde | 21.08.2021 | Vitória Setúbal [A-jun] | - | Sporting CP [A-jun] | 0:1 | ||||
| 4. Ronde | 28.08.2021 | FC Alverca [A-jun] | - | Vitória Setúbal [A-jun] | 6:1 |  |
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| 2. Ronde | 04.09.2021 | Vitória Setúbal [A-jun] | - | União Leiria [A-jun] | 4:3 | |
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| 6. Ronde | 18.09.2021 | CD Nacional [A-jun] | - | Vitória Setúbal [A-jun] | 3:2 | ||||
| 7. Ronde | 25.09.2021 | Vitória Setúbal [A-jun] | - | SL Benfica [A-jun] | 1:1 | ||||
| 8. Ronde | 02.10.2021 | Os Belenenses [A-jun] | - | Vitória Setúbal [A-jun] | 1:1 | ||||
| 13. Ronde | 20.11.2021 | União Leiria [A-jun] | - | Vitória Setúbal [A-jun] | 0:4 | ||||
| 14. Ronde | 27.11.2021 | Sporting CP [A-jun] | - | Vitória Setúbal [A-jun] | 4:0 | ||||
| 15. Ronde | 01.12.2021 | Vitória Setúbal [A-jun] | - | FC Alverca [A-jun] | 0:4 | |
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| 16. Ronde | 04.12.2021 | Amora FC [A-jun] | - | Vitória Setúbal [A-jun] | 0:3 | |
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| 17. Ronde | 11.12.2021 | Vitória Setúbal [A-jun] | - | CD Nacional [A-jun] | 1:1 | ||||
| 19. Ronde | 08.01.2022 | Vitória Setúbal [A-jun] | - | Os Belenenses [A-jun] | 2:1 | ||||
| 20. Ronde | 15.01.2022 | UD Vilafranquense [A-jun] | - | Vitória Setúbal [A-jun] | 0:1 |
Portugal