| 15. Ronde | 05.10.2021 | Central Español | - | Defensor Sporting | 1:0 |  |
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| 19. Ronde | 02.11.2021 | Juventud de Las Piedras | - | Defensor Sporting | 3:3 | ||||
| 20. Ronde | 10.11.2021 | Defensor Sporting | - | Uruguay Montevideo | 2:0 | |
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| 21. Ronde | 18.11.2021 | Rampla Juniors | - | Defensor Sporting | 0:5 | ||||
| 22. Ronde | 24.11.2021 | Defensor Sporting | - | Danubio | 0:1 |
Uruguay