| 1. Ronde | 24.07.2021 | CF Pachuca | - | Club León | 4:0 | ||||
| 2. Ronde | 31.07.2021 | Mazatlán FC | - | CF Pachuca | 2:1 | ||||
| 3. Ronde | 10.08.2021 | CF Pachuca | - | Atlas Guadalajara | 0:1 | ||||
| 6. Ronde | 23.08.2021 | Gallos Blancos | - | CF Pachuca | 0:2 |  |
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| 7. Ronde | 30.08.2021 | Cruz Azul | - | CF Pachuca | 1:1 | ||||
| 8. Ronde | 14.09.2021 | CF Pachuca | - | Deportivo Toluca | 1:2 | ||||
| 10. Ronde | 24.09.2021 | CF Pachuca | - | Club Necaxa | 1:0 |  |
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| 11. Ronde | 29.09.2021 | CF Pachuca | - | CF América | 1:1 | ||||
| 12. Ronde | 02.10.2021 | Puebla FC | - | CF Pachuca | 1:2 | |
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| 16. Ronde | 31.10.2021 | CF Pachuca | - | Pumas UNAM | 1:1 | ||||
| 5. Ronde | 04.11.2021 | CF Pachuca | - | Atlético San Luis | 0:0 | ||||
| 17. Ronde | 07.11.2021 | Club Tijuana | - | CF Pachuca | 3:2 | |
Mexico