| 1. Ronde | 04.04.2021 | Cobreloa | - | Barnechea | 1:2 | ||||
| 2. Ronde | 18.04.2021 | San Marcos | - | Cobreloa | 0:0 | ||||
| 3. Ronde | 26.04.2021 | Cobreloa | - | Universidad de Concepción | 2:4 | ||||
| 4. Ronde | 04.05.2021 | Cobreloa | - | Coquimbo Unido | 1:1 | ||||
| 8. Ronde | 30.05.2021 | Cobreloa | - | San Luis | 1:0 |  |
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| 15. Ronde | 16.08.2021 | Rangers | - | Cobreloa | 4:0 | |
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| 16. Ronde | 24.08.2021 | Barnechea | - | Cobreloa | 1:1 | ||||
| 18. Ronde | 02.09.2021 | Universidad de Concepción | - | Cobreloa | 0:0 | |
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| 19. Ronde | 06.09.2021 | Coquimbo Unido | - | Cobreloa | 2:1 | ||||
| 20. Ronde | 16.09.2021 | Cobreloa | - | Unión San Felipe | 2:1 | ||||
| 21. Ronde | 22.09.2021 | Santiago Morning | - | Cobreloa | 2:1 | ||||
| 22. Ronde | 26.09.2021 | Cobreloa | - | Fernández Vial | 1:2 | ||||
| 25. Ronde | 13.10.2021 | Deportes Iquique | - | Cobreloa | 1:0 | ||||
| 26. Ronde | 16.10.2021 | Cobreloa | - | Deportes Copiapó | 2:0 | |
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| 28. Ronde | 02.11.2021 | Cobreloa | - | Deportes Temuco | 0:2 | ||||
| 29. Ronde | 07.11.2021 | Santa Cruz | - | Cobreloa | 2:2 | ||||
| 30. Ronde | 13.11.2021 | Cobreloa | - | Rangers | 4:1 |  |
Chili