| 1. Ronde | 08.08.2020 | MFK Zemplín Michalovce | - | Spartak Trnava | 0:2 |  |
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| 2. Ronde | 11.08.2020 | Spartak Trnava | - | MFK Ružomberok | 3:1 | ||||
| 4. Ronde | 22.08.2020 | FC DAC 1904 | - | Spartak Trnava | 2:1 | ||||
| 5. Ronde | 29.08.2020 | Spartak Trnava | - | ŠKF Sereď | 0:2 | ||||
| 6. Ronde | 12.09.2020 | Slovan Bratislava | - | Spartak Trnava | 2:0 | |
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| 7. Ronde | 19.09.2020 | Spartak Trnava | - | Zlaté Moravce | 1:0 | ||||
| 8. Ronde | 26.09.2020 | FK Senica | - | Spartak Trnava | 0:2 | ||||
| 9. Ronde | 03.10.2020 | Spartak Trnava | - | FC Nitra | 0:2 | ||||
| 10. Ronde | 18.10.2020 | MŠK Žilina | - | Spartak Trnava | 2:1 |  |
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| 13. Ronde | 07.11.2020 | MFK Ružomberok | - | Spartak Trnava | 0:1 | ||||
| 14. Ronde | 21.11.2020 | FK Pohronie | - | Spartak Trnava | 3:3 | |
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| 15. Ronde | 28.11.2020 | Spartak Trnava | - | FC DAC 1904 | 0:2 | ||||
| 16. Ronde | 05.12.2020 | ŠKF Sereď | - | Spartak Trnava | 2:6 | ||||
| 17. Ronde | 13.12.2020 | Spartak Trnava | - | Slovan Bratislava | 0:3 | |
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| 19. Ronde | 13.02.2021 | Spartak Trnava | - | FK Senica | 1:0 | |
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| 20. Ronde | 20.02.2021 | FC Nitra | - | Spartak Trnava | 0:1 | ||||
| 21. Ronde | 27.02.2021 | Spartak Trnava | - | MŠK Žilina | 2:1 | |
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| 22. Ronde | 06.03.2021 | AS Trenčín | - | Spartak Trnava | 2:0 |
Slowakije