| 3. Ronde | 23.01.2022 | Pumas UNAM [U18] | - | UANL Tigres [U18] | 1:4 | ||||
| 14. Ronde | 27.01.2022 | Pumas UNAM [U18] | - | CF Monterrey [U18] | 4:2 | ||||
| 4. Ronde | 05.02.2022 | Club Tijuana [U18] | - | Pumas UNAM [U18] | 2:0 |  |
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| 6. Ronde | 20.02.2022 | Atlas Guadalajara [U18] | - | Pumas UNAM [U18] | 5:2 | ||||
| 7. Ronde | 26.02.2022 | Pumas UNAM [U18] | - | CF América [U18] | 0:1 | ||||
| 8. Ronde | 02.03.2022 | Santos Laguna [U18] | - | Pumas UNAM [U18] | 0:0 | |
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| 10. Ronde | 11.03.2022 | Cruz Azul [U18] | - | Pumas UNAM [U18] | 0:2 | |
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| 11. Ronde | 19.03.2022 | Pumas UNAM [U18] | - | Club Necaxa [U18] | 0:0 | ||||
| 9. Ronde | 26.03.2022 | Pumas UNAM [U18] | - | Mazatlán FC [U18] | 3:0 | ||||
| 12. Ronde | 02.04.2022 | FC Juárez [U18] | - | Pumas UNAM [U18] | 1:2 | ||||
| 13. Ronde | 08.04.2022 | Puebla FC [U18] | - | Pumas UNAM [U18] | 2:4 |  |
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| 15. Ronde | 20.04.2022 | Atlético San Luis [U18] | - | Pumas UNAM [U18] | 2:1 | |
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| 17. Ronde | 01.05.2022 | Pumas UNAM [U18] | - | CF Pachuca [U18] | 0:1 |
Mexico