| 1. Ronde | 07.08.2021 | St-Pryvé St-Hilaire | - | US Saint-Malo | 1:0 |  |
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| 2. Ronde | 14.08.2021 | US Saint-Malo | - | Blois Foot 41 | 1:2 | ||||
| 3. Ronde | 21.08.2021 | FC Lorient B | - | US Saint-Malo | 2:0 | ||||
| 4. Ronde | 28.08.2021 | US Saint-Malo | - | EA Guingamp B | 0:2 | |
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| 5. Ronde | 04.09.2021 | AS Poissy | - | US Saint-Malo | 1:1 | |
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| 6. Ronde | 11.09.2021 | US Saint-Malo | - | C'Chartres Football | 2:1 | ||||
| 8. Ronde | 25.09.2021 | US Saint-Malo | - | Vannes OC | 2:2 | ||||
| 11. Ronde | 07.11.2021 | FC Rouen 1899 | - | US Saint-Malo | 0:1 | ||||
| 17. Ronde | 05.02.2022 | US Saint-Malo | - | FC Lorient B | 2:0 | |
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| 18. Ronde | 12.02.2022 | EA Guingamp B | - | US Saint-Malo | 0:0 | |
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| 19. Ronde | 19.02.2022 | US Saint-Malo | - | AS Poissy | 2:0 | ||||
| 20. Ronde | 05.03.2022 | C'Chartres Football | - | US Saint-Malo | 2:1 | ||||
| 21. Ronde | 12.03.2022 | US Saint-Malo | - | Châteaubriant Voltigeurs | 3:2 | ||||
| 22. Ronde | 19.03.2022 | Vannes OC | - | US Saint-Malo | 3:2 | ||||
| 23. Ronde | 26.03.2022 | US Saint-Malo | - | US Granvillaise | 1:0 | ||||
| 24. Ronde | 09.04.2022 | SO Romorantin | - | US Saint-Malo | 2:1 | ||||
| 25. Ronde | 16.04.2022 | US Saint-Malo | - | FC Rouen 1899 | 1:4 | ||||
| 28. Ronde | 14.05.2022 | US Saint-Malo | - | SM Caen B | 1:0 |  |
Frankrijk