| 5. Ronde | 12.02.2022 | Cruz Azul [U18] | - | Club Necaxa [U18] | 2:1 |  |
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| 6. Ronde | 20.02.2022 | Deportivo Toluca [U18] | - | Cruz Azul [U18] | 1:1 | ||||
| 7. Ronde | 27.02.2022 | Cruz Azul [U18] | - | Santos Laguna [U18] | 1:2 | ||||
| 8. Ronde | 02.03.2022 | UANL Tigres [U18] | - | Cruz Azul [U18] | 2:0 | ||||
| 9. Ronde | 05.03.2022 | Cruz Azul [U18] | - | Puebla FC [U18] | 2:0 | ||||
| 10. Ronde | 11.03.2022 | Cruz Azul [U18] | - | Pumas UNAM [U18] | 0:2 |  |
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| 11. Ronde | 19.03.2022 | CF Pachuca [U18] | - | Cruz Azul [U18] | 3:2 | |
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| 12. Ronde | 02.04.2022 | Cruz Azul [U18] | - | Atlas Guadalajara [U18] | 1:1 | ||||
| 13. Ronde | 08.04.2022 | Mazatlán FC [U18] | - | Cruz Azul [U18] | 1:2 | ||||
| 14. Ronde | 16.04.2022 | Cruz Azul [U18] | - | Deportivo Guadalajara [U18] | 1:0 | ||||
| 15. Ronde | 21.04.2022 | Gallos Blancos [U18] | - | Cruz Azul [U18] | 1:1 | ||||
| 16. Ronde | 24.04.2022 | Cruz Azul [U18] | - | Atlético San Luis [U18] | 2:1 | ||||
| 17. Ronde | 30.04.2022 | CF América [U18] | - | Cruz Azul [U18] | 3:2 |
Mexico