| 1. Ronde | 07.01.2023 | Santos Laguna [] | - | Atlético San Luis [] | 5:0 |  |
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| 2. Ronde | 14.01.2023 | Atlas Guadalajara [] | - | Santos Laguna [] | 1:3 | |
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| 5. Ronde | 05.02.2023 | Santos Laguna [] | - | Club León [] | 3:0 | |
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| 6. Ronde | 11.02.2023 | Deportivo Guadalajara [] | - | Santos Laguna [] | 0:0 | ||||
| 7. Ronde | 18.02.2023 | Club Tijuana [] | - | Santos Laguna [] | 2:0 | ||||
| 8. Ronde | 25.02.2023 | Santos Laguna [] | - | Mazatlán FC [] | 2:0 | ||||
| 10. Ronde | 11.03.2023 | Santos Laguna [] | - | Atlas Guadalajara [] | 3:0 | |
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| 12. Ronde | 25.03.2023 | CF Monterrey [] | - | Santos Laguna [] | 2:1 | ||||
| 14. Ronde | 08.04.2023 | Mazatlán FC [] | - | Santos Laguna [] | 0:1 | ||||
| 15. Ronde | 15.04.2023 | Santos Laguna [] | - | Deportivo Guadalajara [] | 5:3 | |
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| 18. Ronde | 06.05.2023 | Santos Laguna [] | - | Club Tijuana [] | 2:2 |
Mexico