| 1. Ronde | 14.08.2021 | Hamburger SV [A-jun] | - | RB Leipzig [A-jun] | 0:3 |  |
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| 2. Ronde | 21.08.2021 | RB Leipzig [A-jun] | - | FC St. Pauli [A-jun] | 2:2 | ||||
| 3. Ronde | 11.09.2021 | FC Carl Zeiss Jena [A-jun] | - | RB Leipzig [A-jun] | 0:1 | |
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| 5. Ronde | 25.09.2021 | Holstein Kiel [A-jun] | - | RB Leipzig [A-jun] | 2:2 | ||||
| 8. Ronde | 23.10.2021 | Eimsbütteler TV [A-jun] | - | RB Leipzig [A-jun] | 3:6 |  |
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| 9. Ronde | 29.10.2021 | RB Leipzig [A-jun] | - | Dynamo Dresden [A-jun] | 0:3 | |
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| 10. Ronde | 20.11.2021 | FC Viktoria 1889 Berlin [A-jun] | - | RB Leipzig [A-jun] | 0:0 | ||||
| 11. Ronde | 12.02.2022 | RB Leipzig [A-jun] | - | Hallescher FC [A-jun] | 7:0 | ||||
| 14. Ronde | 26.02.2022 | Hertha BSC [A-jun] | - | RB Leipzig [A-jun] | 1:4 | ||||
| 15. Ronde | 05.03.2022 | RB Leipzig [A-jun] | - | 1. FC Magdeburg [A-jun] | 1:3 | ||||
| 12. Ronde | 12.03.2022 | VfL Wolfsburg [A-jun] | - | RB Leipzig [A-jun] | 0:1 | ||||
| 16. Ronde | 02.04.2022 | 1. FC Union Berlin [A-jun] | - | RB Leipzig [A-jun] | 1:2 | ||||
| 17. Ronde | 09.04.2022 | RB Leipzig [A-jun] | - | Hannover 96 [A-jun] | 2:0 | |
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| 19. Ronde | 30.04.2022 | RB Leipzig [A-jun] | - | Energie Cottbus [A-jun] | 1:1 |
Duitsland