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| 05.03.2022 | 11:00 | FC St. Pauli | - | Energie Cottbus | 0:2 (0:2) | |
| 11:00 | FC Viktoria 1889 Berlin | - | Hallescher FC | 2:1 (1:0) | ||
| 11:00 | Dynamo Dresden | - | VfL Wolfsburg | 0:1 (0:1) | ||
| 11:00 | Holstein Kiel | - | 1. FC Union Berlin | 2:0 (1:0) | ||
| 11:00 | FC Carl Zeiss Jena | - | Hansa Rostock | 0:3 (0:1) | ||
| 12:00 | RB Leipzig | - | 1. FC Magdeburg | 1:3 (0:1) | ||
| 13:00 | Eimsbütteler TV | - | Werder Bremen | 0:0 (0:0) | ||
| 14:00 | Chemnitzer FC | - | Hertha BSC | 3:1 (3:1) | ||
| 15:00 | VfL Osnabrück | - | Hannover 96 | 1:1 (1:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Hertha BSC | 14 | 11 | 1 | 2 | 37:19 | 18 | 34 |
| 2 |
|
Energie Cottbus | 14 | 10 | 2 | 2 | 26:15 | 11 | 32 |
| 3 |
|
Werder Bremen | 14 | 9 | 1 | 4 | 35:27 | 8 | 28 |
| 4 |
|
RB Leipzig | 14 | 8 | 3 | 3 | 36:17 | 19 | 27 |
| 5 |
|
Holstein Kiel | 14 | 8 | 2 | 4 | 24:21 | 3 | 26 |
| 6 |
|
FC Viktoria 1889 Berlin | 14 | 6 | 6 | 2 | 25:17 | 8 | 24 |
| 7 |
|
1. FC Union Berlin | 14 | 6 | 4 | 4 | 22:21 | 1 | 22 |
| 8 |
|
VfL Wolfsburg | 15 | 5 | 5 | 5 | 19:20 | -1 | 20 |
| 9 |
|
Dynamo Dresden | 14 | 6 | 1 | 7 | 20:15 | 5 | 19 |
| 10 |
|
Hannover 96 | 14 | 5 | 4 | 5 | 20:19 | 1 | 19 |
| 11 |
|
Hansa Rostock | 14 | 5 | 3 | 6 | 27:20 | 7 | 18 |
| 12 |
|
Hallescher FC | 15 | 5 | 3 | 7 | 15:29 | -14 | 18 |
| 13 |
|
1. FC Magdeburg | 14 | 5 | 1 | 8 | 26:26 | 0 | 16 |
| 14 |
|
Hamburger SV | 14 | 4 | 4 | 6 | 24:29 | -5 | 16 |
| 15 |
|
Chemnitzer FC | 14 | 4 | 4 | 6 | 16:21 | -5 | 16 |
| 16 |
|
FC St. Pauli | 15 | 4 | 3 | 8 | 22:33 | -11 | 15 |
| 17 |
|
VfL Osnabrück | 14 | 3 | 4 | 7 | 16:28 | -12 | 13 |
| 18 |
|
Eimsbütteler TV | 14 | 2 | 3 | 9 | 13:27 | -14 | 9 |
| 19 |
|
FC Carl Zeiss Jena | 15 | 1 | 2 | 12 | 12:31 | -19 | 5 |
| Play-offs | |
| Degradatie |
