| 1. Ronde | 17.02.2022 | Cobreloa | - | San Luis | 2:1 |  |
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| 2. Ronde | 25.02.2022 | Universidad de Concepción | - | Cobreloa | 0:2 |  |
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| 4. Ronde | 09.03.2022 | Rangers | - | Cobreloa | 1:2 | ||||
| 6. Ronde | 23.03.2022 | CD Magallanes | - | Cobreloa | 2:1 | |
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| 7. Ronde | 02.04.2022 | Cobreloa | - | Puerto Montt | 2:1 | ||||
| 15. Ronde | 18.05.2022 | Deportes Temuco | - | Cobreloa | 2:0 | ||||
| 17. Ronde | 28.05.2022 | Santiago Morning | - | Cobreloa | 0:1 | ||||
| 5. Ronde | 02.06.2022 | Cobreloa | - | Santa Cruz | 1:0 | ||||
| 3. Ronde | 06.06.2022 | Cobreloa | - | Deportes Copiapó | 2:0 | |
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| 24. Ronde | 12.08.2022 | Puerto Montt | - | Cobreloa | 1:1 | ||||
| 25. Ronde | 25.08.2022 | Cobreloa | - | Deportes Melipilla | 1:0 | ||||
| 26. Ronde | 31.08.2022 | Cobreloa | - | Deportes Iquique | 2:1 | ||||
| 27. Ronde | 07.09.2022 | Barnechea | - | Cobreloa | 0:1 | ||||
| 28. Ronde | 15.09.2022 | Recoleta | - | Cobreloa | 0:1 | ||||
| 29. Ronde | 26.09.2022 | Cobreloa | - | Unión San Felipe | 1:0 | ||||
| 31. Ronde | 09.10.2022 | Santiago Wanderers | - | Cobreloa | 2:2 |  |
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| 34. Ronde | 01.11.2022 | Cobreloa | - | Santiago Morning | 2:2 |
Chili