| 2. Ronde | 16.01.2021 | Deportivo Guadalajara [U20] | - | Deportivo Toluca [U20] | 5:3 |  |
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| 3. Ronde | 21.01.2021 | Atlético San Luis [U20] | - | Deportivo Guadalajara [U20] | 3:2 | ||||
| 4. Ronde | 30.01.2021 | Deportivo Guadalajara [U20] | - | FC Juárez [U20] | 0:1 | ||||
| 5. Ronde | 08.02.2021 | Club León [U20] | - | Deportivo Guadalajara [U20] | 3:0 | ||||
| 6. Ronde | 13.02.2021 | Deportivo Guadalajara [U20] | - | Club Necaxa [U20] | 1:0 | ||||
| 8. Ronde | 28.02.2021 | Deportivo Guadalajara [U20] | - | Pumas UNAM [U20] | 1:2 | ||||
| 12. Ronde | 20.03.2021 | CF Monterrey [U20] | - | Deportivo Guadalajara [U20] | 1:0 | ||||
| 14. Ronde | 10.04.2021 | Cruz Azul [U20] | - | Deportivo Guadalajara [U20] | 0:1 | ||||
| 16. Ronde | 24.04.2021 | Atlas Guadalajara [U20] | - | Deportivo Guadalajara [U20] | 3:2 | ||||
| 17. Ronde | 01.05.2021 | Deportivo Guadalajara [U20] | - | UANL Tigres [U20] | 1:1 | |
Mexico