| 4. Ronde | 21.08.2005 | Dorados de Sinaloa | - | Santos Laguna | 0:3 | ||||
| 5. Ronde | 25.08.2005 | CF América | - | Santos Laguna | 2:1 | ||||
| 6. Ronde | 28.08.2005 | Santos Laguna | - | Deportivo Guadalajara | 3:0 |  |
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| 7. Ronde | 11.09.2005 | Club Necaxa | - | Santos Laguna | 4:3 | |
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| 8. Ronde | 18.09.2005 | Santos Laguna | - | Club San Luis | 3:1 | ||||
| 9. Ronde | 24.09.2005 | Veracruz (old) | - | Santos Laguna | 2:2 | ||||
| 10. Ronde | 29.09.2005 | Santos Laguna | - | Cruz Azul | 3:2 |  |
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| 11. Ronde | 02.10.2005 | CF Monterrey | - | Santos Laguna | 2:2 | ||||
| 12. Ronde | 16.10.2005 | Santos Laguna | - | CF Pachuca | 0:0 | ||||
| 13. Ronde | 23.10.2005 | Monarcas Morelia | - | Santos Laguna | 1:0 | ||||
| 15. Ronde | 05.11.2005 | UAG Tecos | - | Santos Laguna | 3:2 | ||||
| 16. Ronde | 20.11.2005 | Santos Laguna | - | Deportivo Toluca | 4:1 | ||||
| 17. Ronde | 26.11.2005 | Jaguares Chiapas | - | Santos Laguna | 5:1 |
Mexico