| 1. Ronde | 08.08.2020 | FK Senica | - | MŠK Žilina | 0:4 | ||||
| 2. Ronde | 12.08.2020 | ŠKF Sereď | - | FK Senica | 4:0 |  |
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| 5. Ronde | 29.08.2020 | FK Senica | - | FC Nitra | 0:0 | ||||
| 6. Ronde | 11.09.2020 | Zlaté Moravce | - | FK Senica | 2:2 | ||||
| 7. Ronde | 20.09.2020 | FK Senica | - | FC DAC 1904 | 2:4 | ||||
| 8. Ronde | 26.09.2020 | FK Senica | - | Spartak Trnava | 0:2 | ||||
| 4. Ronde | 30.09.2020 | Slovan Bratislava | - | FK Senica | 2:0 | ||||
| 9. Ronde | 04.10.2020 | AS Trenčín | - | FK Senica | 0:1 | ||||
| 11. Ronde | 24.10.2020 | FK Pohronie | - | FK Senica | 1:2 |  |
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| 12. Ronde | 31.10.2020 | MŠK Žilina | - | FK Senica | 3:1 | ||||
| 13. Ronde | 17.11.2020 | FK Senica | - | ŠKF Sereď | 2:2 | ||||
| 14. Ronde | 21.11.2020 | MFK Zemplín Michalovce | - | FK Senica | 0:1 | ||||
| 15. Ronde | 29.11.2020 | FK Senica | - | Slovan Bratislava | 0:3 | ||||
| 16. Ronde | 05.12.2020 | FC Nitra | - | FK Senica | 1:1 | ||||
| 17. Ronde | 12.12.2020 | FK Senica | - | Zlaté Moravce | 1:1 | |
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| 18. Ronde | 15.12.2020 | FC DAC 1904 | - | FK Senica | 2:0 | ||||
| 19. Ronde | 13.02.2021 | Spartak Trnava | - | FK Senica | 1:0 | ||||
| 20. Ronde | 20.02.2021 | FK Senica | - | AS Trenčín | 2:3 | ||||
| 21. Ronde | 27.02.2021 | MFK Ružomberok | - | FK Senica | 2:3 | ||||
| 22. Ronde | 06.03.2021 | FK Senica | - | FK Pohronie | 1:1 |
Slowakije