| 4. Ronde | 29.01.2021 | Mazatlán FC [U20] | - | CF Pachuca [U20] | 1:3 | ||||
| 5. Ronde | 07.02.2021 | Deportivo Toluca [U20] | - | Mazatlán FC [U20] | 3:1 | ||||
| 7. Ronde | 19.02.2021 | FC Juárez [U20] | - | Mazatlán FC [U20] | 2:2 | ||||
| 9. Ronde | 03.03.2021 | Cruz Azul [U20] | - | Mazatlán FC [U20] | 2:2 | ||||
| 11. Ronde | 13.03.2021 | UANL Tigres [U20] | - | Mazatlán FC [U20] | 2:1 | ||||
| 13. Ronde | 02.04.2021 | Puebla FC [U20] | - | Mazatlán FC [U20] | 6:2 |  |
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| 14. Ronde | 12.04.2021 | Club Tijuana [U20] | - | Mazatlán FC [U20] | 1:0 | ||||
| 16. Ronde | 23.04.2021 | Mazatlán FC [U20] | - | Club León [U20] | 1:3 |
Mexico