| 1. Ronde | 10.01.2021 | UANL Tigres | - | Club León | 2:0 | ||||
| 2. Ronde | 19.01.2021 | Club León | - | CF Pachuca | 0:0 | ||||
| 5. Ronde | 09.02.2021 | Club León | - | Deportivo Guadalajara | 1:3 | ||||
| 6. Ronde | 13.02.2021 | Club Tijuana | - | Club León | 2:0 | ||||
| 7. Ronde | 21.02.2021 | Pumas UNAM | - | Club León | 0:1 | ||||
| 9. Ronde | 03.03.2021 | Club León | - | Puebla FC | 1:2 | ||||
| 10. Ronde | 07.03.2021 | CF América | - | Club León | 2:1 | ||||
| 3. Ronde | 11.03.2021 | CF Monterrey | - | Club León | 1:1 | ||||
| 11. Ronde | 16.03.2021 | Club León | - | Club Necaxa | 3:1 | ||||
| 12. Ronde | 22.03.2021 | Santos Laguna | - | Club León | 1:2 | ||||
| 13. Ronde | 05.04.2021 | Club León | - | Deportivo Toluca | 2:1 | ||||
| 14. Ronde | 11.04.2021 | Atlas Guadalajara | - | Club León | 1:3 |  |
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| 15. Ronde | 20.04.2021 | Club León | - | FC Juárez | 2:0 | ||||
| 16. Ronde | 24.04.2021 | Mazatlán FC | - | Club León | 4:3 | ||||
| 17. Ronde | 02.05.2021 | Club León | - | Gallos Blancos | 2:1 |  |
Mexico