| 3. Ronde | 08.08.2020 | CF Monterrey [U20] | - | Santos Laguna [U20] | 2:1 | ||||
| 4. Ronde | 13.08.2020 | CF América [U20] | - | Santos Laguna [U20] | 4:0 | ||||
| 8. Ronde | 04.09.2020 | FC Juárez [U20] | - | Santos Laguna [U20] | 0:1 |  |
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| 9. Ronde | 09.09.2020 | Santos Laguna [U20] | - | Pumas UNAM [U20] | 1:3 | |
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| 10. Ronde | 12.09.2020 | UANL Tigres [U20] | - | Santos Laguna [U20] | 2:0 | ||||
| 11. Ronde | 20.09.2020 | Deportivo Toluca [U20] | - | Santos Laguna [U20] | 1:0 | ||||
| 12. Ronde | 27.09.2020 | Santos Laguna [U20] | - | Club Tijuana [U20] | 5:1 | ||||
| 13. Ronde | 02.10.2020 | Puebla FC [U20] | - | Santos Laguna [U20] | 2:1 | ||||
| 1. Ronde | 10.10.2020 | Cruz Azul [U20] | - | Santos Laguna [U20] | 2:1 | ||||
| 15. Ronde | 25.10.2020 | Santos Laguna [U20] | - | Atlético San Luis [U20] | 2:1 | ||||
| 17. Ronde | 08.11.2020 | Santos Laguna [U20] | - | Mazatlán FC [U20] | 4:1 |  |
Mexico