| 2. Ronde | 17.01.2021 | Santos Laguna [U20] | - | UANL Tigres [U20] | 2:0 | ||||
| 3. Ronde | 22.01.2021 | Mazatlán FC [U20] | - | Santos Laguna [U20] | 2:2 |  |
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| 4. Ronde | 31.01.2021 | Santos Laguna [U20] | - | CF América [U20] | 0:1 | ||||
| 5. Ronde | 06.02.2021 | Atlas Guadalajara [U20] | - | Santos Laguna [U20] | 0:0 | ||||
| 6. Ronde | 14.02.2021 | Santos Laguna [U20] | - | CF Monterrey [U20] | 1:2 |  |
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| 8. Ronde | 28.02.2021 | Santos Laguna [U20] | - | FC Juárez [U20] | 3:0 | ||||
| 9. Ronde | 04.03.2021 | Pumas UNAM [U20] | - | Santos Laguna [U20] | 0:0 | ||||
| 10. Ronde | 07.03.2021 | Santos Laguna [U20] | - | Club Necaxa [U20] | 1:1 | ||||
| 11. Ronde | 14.03.2021 | Club Tijuana [U20] | - | Santos Laguna [U20] | 3:1 | ||||
| 12. Ronde | 21.03.2021 | Santos Laguna [U20] | - | Club León [U20] | 3:0 | ||||
| 1. Ronde | 26.03.2021 | Santos Laguna [U20] | - | Cruz Azul [U20] | 3:1 | ||||
| 13. Ronde | 04.04.2021 | Deportivo Guadalajara [U20] | - | Santos Laguna [U20] | 5:2 | ||||
| 14. Ronde | 11.04.2021 | Gallos Blancos [U20] | - | Santos Laguna [U20] | 1:0 | ||||
| 15. Ronde | 18.04.2021 | Santos Laguna [U20] | - | Deportivo Toluca [U20] | 2:2 | |
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| 17. Ronde | 02.05.2021 | Santos Laguna [U20] | - | Puebla FC [U20] | 2:3 |
Mexico