| 2. Ronde | 18.04.2021 | San Marcos | - | Cobreloa | 0:0 | ||||
| 3. Ronde | 26.04.2021 | Cobreloa | - | Universidad de Concepción | 2:4 | ||||
| 9. Ronde | 07.06.2021 | CD Magallanes | - | Cobreloa | 2:2 | ||||
| 19. Ronde | 06.09.2021 | Coquimbo Unido | - | Cobreloa | 2:1 | ||||
| 25. Ronde | 13.10.2021 | Deportes Iquique | - | Cobreloa | 1:0 | ||||
| 26. Ronde | 16.10.2021 | Cobreloa | - | Deportes Copiapó | 2:0 | ||||
| 28. Ronde | 02.11.2021 | Cobreloa | - | Deportes Temuco | 0:2 | ||||
| 29. Ronde | 07.11.2021 | Santa Cruz | - | Cobreloa | 2:2 | ||||
| 30. Ronde | 13.11.2021 | Cobreloa | - | Rangers | 4:1 |
Chili