| 1. Ronde | 08.08.2021 | RC Strasbourg | - | Angers SCO | 0:2 | ||||
| 2. Ronde | 15.08.2021 | Angers SCO | - | Olympique Lyonnais | 3:0 | ||||
| 3. Ronde | 22.08.2021 | Girondins Bordeaux | - | Angers SCO | 1:1 | ||||
| 4. Ronde | 29.08.2021 | Angers SCO | - | Stade Rennais | 2:0 | ||||
| 5. Ronde | 12.09.2021 | Stade Brestois 29 | - | Angers SCO | 1:1 | ||||
| 6. Ronde | 19.09.2021 | Angers SCO | - | FC Nantes | 1:4 | ||||
| 7. Ronde | 22.09.2021 | Angers SCO | - | Olympique Marseille | 0:0 | ||||
| 8. Ronde | 26.09.2021 | ESTAC Troyes | - | Angers SCO | 1:1 | ||||
| 9. Ronde | 03.10.2021 | Angers SCO | - | FC Metz | 3:2 | ||||
| 10. Ronde | 15.10.2021 | Paris Saint-Germain | - | Angers SCO | 2:1 | ||||
| 11. Ronde | 22.10.2021 | AS Saint-Étienne | - | Angers SCO | 2:2 | ||||
| 12. Ronde | 31.10.2021 | Angers SCO | - | OGC Nice | 1:2 | ||||
| 19. Ronde | 22.12.2021 | Montpellier HSC | - | Angers SCO | 4:1 |
Frankrijk