| 1. Ronde | 26.07.2021 | Cruz Azul [U20] | - | Mazatlán FC [U20] | 1:1 |  |
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| 2. Ronde | 01.08.2021 | Santos Laguna [U20] | - | Cruz Azul [U20] | 1:0 | ||||
| 3. Ronde | 06.08.2021 | Club Necaxa [U20] | - | Cruz Azul [U20] | 1:0 | ||||
| 8. Ronde | 10.09.2021 | FC Juárez [U20] | - | Cruz Azul [U20] | 0:1 | ||||
| 12. Ronde | 04.10.2021 | Club Tijuana [U20] | - | Cruz Azul [U20] | 0:1 | ||||
| 14. Ronde | 19.10.2021 | Atlas Guadalajara [U20] | - | Cruz Azul [U20] | 0:0 | ||||
| 11. Ronde | 03.11.2021 | Cruz Azul [U20] | - | Club León [U20] | 2:0 | ||||
| 17. Ronde | 07.11.2021 | Pumas UNAM [U20] | - | Cruz Azul [U20] | 1:2 |
Mexico