| 10. Ronde | 18.10.2020 | MŠK Žilina | - | Spartak Trnava | 2:1 | ||||
| 11. Ronde | 24.10.2020 | Spartak Trnava | - | AS Trenčín | 2:0 | ||||
| 12. Ronde | 31.10.2020 | Spartak Trnava | - | MFK Zemplín Michalovce | 1:2 | ||||
| 13. Ronde | 07.11.2020 | MFK Ružomberok | - | Spartak Trnava | 0:1 |  |
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| 14. Ronde | 21.11.2020 | FK Pohronie | - | Spartak Trnava | 3:3 | ||||
| 15. Ronde | 28.11.2020 | Spartak Trnava | - | FC DAC 1904 | 0:2 | ||||
| 16. Ronde | 05.12.2020 | ŠKF Sereď | - | Spartak Trnava | 2:6 | ||||
| 17. Ronde | 13.12.2020 | Spartak Trnava | - | Slovan Bratislava | 0:3 | |
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| 18. Ronde | 06.02.2021 | Zlaté Moravce | - | Spartak Trnava | 2:4 | |
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| 19. Ronde | 13.02.2021 | Spartak Trnava | - | FK Senica | 1:0 | ||||
| 20. Ronde | 20.02.2021 | FC Nitra | - | Spartak Trnava | 0:1 | ||||
| 21. Ronde | 27.02.2021 | Spartak Trnava | - | MŠK Žilina | 2:1 | ||||
| 22. Ronde | 06.03.2021 | AS Trenčín | - | Spartak Trnava | 2:0 |
Slowakije