| 2. Ronde | 16.01.2022 | Atlas Guadalajara | - | Atlético San Luis | 1:0 |  |
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| 3. Ronde | 21.01.2022 | Atlético San Luis | - | FC Juárez | 0:1 | ||||
| 4. Ronde | 06.02.2022 | CF América | - | Atlético San Luis | 2:3 | ||||
| 5. Ronde | 13.02.2022 | Atlético San Luis | - | Deportivo Toluca | 0:1 | |
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| 6. Ronde | 20.02.2022 | UANL Tigres | - | Atlético San Luis | 2:1 | |
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| 7. Ronde | 27.02.2022 | CF Monterrey | - | Atlético San Luis | 0:2 | |
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| 8. Ronde | 03.03.2022 | Atlético San Luis | - | Deportivo Guadalajara | 2:2 |  |
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| 11. Ronde | 18.03.2022 | Gallos Blancos | - | Atlético San Luis | 2:1 |  |
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| 13. Ronde | 10.04.2022 | Atlético San Luis | - | Club León | 2:0 | ||||
| 15. Ronde | 21.04.2022 | Atlético San Luis | - | Pumas UNAM | 2:0 | ||||
| 16. Ronde | 25.04.2022 | Cruz Azul | - | Atlético San Luis | 0:1 | ||||
| 17. Ronde | 01.05.2022 | Atlético San Luis | - | Santos Laguna | 1:3 |
Mexico