| 1. Ronde | 18.09.2021 | CF Pachuca [] | - | Deportivo Toluca [] | 5:0 | ||||
| 2. Ronde | 25.09.2021 | Cruz Azul [] | - | CF Pachuca [] | 3:6 | ||||
| 3. Ronde | 02.10.2021 | CF Pachuca [] | - | Puebla FC [] | 4:0 | ||||
| 4. Ronde | 09.10.2021 | Pumas UNAM [] | - | CF Pachuca [] | 1:1 | ||||
| 5. Ronde | 16.10.2021 | CF Pachuca [] | - | FC Juárez [] | 7:0 | ||||
| 6. Ronde | 23.10.2021 | Club Tijuana [] | - | CF Pachuca [] | 4:2 |
Verenigde Staten