| 1. Ronde | 04.04.2021 | Cobreloa | - | Barnechea | 1:2 | ||||
| 2. Ronde | 17.04.2021 | Barnechea | - | Coquimbo Unido | 0:1 | ||||
| 4. Ronde | 03.05.2021 | Barnechea | - | Deportes Iquique | 3:1 | ||||
| 5. Ronde | 11.05.2021 | Rangers | - | Barnechea | 2:0 | ||||
| 6. Ronde | 18.05.2021 | Barnechea | - | Puerto Montt | 0:1 | ||||
| 7. Ronde | 25.05.2021 | Deportes Temuco | - | Barnechea | 2:0 | ||||
| 8. Ronde | 30.05.2021 | Barnechea | - | CD Magallanes | 0:1 | ||||
| 9. Ronde | 06.06.2021 | Unión San Felipe | - | Barnechea | 2:4 | ||||
| 13. Ronde | 03.08.2021 | Barnechea | - | Santa Cruz | 0:0 | ||||
| 14. Ronde | 07.08.2021 | Deportes Copiapó | - | Barnechea | 1:1 | ||||
| 15. Ronde | 17.08.2021 | Barnechea | - | San Luis | 0:0 | ||||
| 16. Ronde | 24.08.2021 | Barnechea | - | Cobreloa | 1:1 | ||||
| 17. Ronde | 28.08.2021 | Coquimbo Unido | - | Barnechea | 1:1 | ||||
| 18. Ronde | 02.09.2021 | Barnechea | - | Fernández Vial | 0:3 | ||||
| 19. Ronde | 05.09.2021 | Deportes Iquique | - | Barnechea | 4:2 | ||||
| 20. Ronde | 16.09.2021 | Barnechea | - | Rangers | 2:3 |
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