| 4. Ronde | 30.01.2011 | Jaguares Chiapas | - | Santos Laguna | 1:2 | ||||
| 6. Ronde | 13.02.2011 | Atlas Guadalajara | - | Santos Laguna | 1:2 | ||||
| 9. Ronde | 06.03.2011 | Santos Laguna | - | CF América | 2:3 | ||||
| 10. Ronde | 13.03.2011 | Deportivo Toluca | - | Santos Laguna | 3:1 | ||||
| 11. Ronde | 20.03.2011 | Santos Laguna | - | Monarcas Morelia | 0:1 |  |
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| 13. Ronde | 10.04.2011 | CF Monterrey | - | Santos Laguna | 1:1 | ||||
| 14. Ronde | 14.04.2011 | Santos Laguna | - | Puebla FC | 4:0 | ||||
| 15. Ronde | 17.04.2011 | Deportivo Guadalajara | - | Santos Laguna | 0:1 | ||||
| 16. Ronde | 24.04.2011 | Santos Laguna | - | Club San Luis | 1:3 | ||||
| 17. Ronde | 30.04.2011 | Estudiantes Tecos | - | Santos Laguna | 1:3 |
Mexico