| 1. Ronde | 15.08.2004 | Santos Laguna | - | Atlas Guadalajara | 2:0 | ||||
| 2. Ronde | 22.08.2004 | Dorados de Sinaloa | - | Santos Laguna | 2:1 | ||||
| 4. Ronde | 12.09.2004 | UAG Tecos | - | Santos Laguna | 1:0 | ||||
| 5. Ronde | 16.09.2004 | Puebla FC | - | Santos Laguna | 1:0 | ||||
| 7. Ronde | 26.09.2004 | CF Monterrey | - | Santos Laguna | 1:0 | ||||
| 9. Ronde | 03.10.2004 | Monarcas Morelia | - | Santos Laguna | 1:1 | ||||
| 10. Ronde | 17.10.2004 | Santos Laguna | - | Deportivo Guadalajara | 4:1 |  |
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| 11. Ronde | 22.10.2004 | Pumas UNAM | - | Santos Laguna | 2:1 | ||||
| 12. Ronde | 24.10.2004 | Santos Laguna | - | Atlante | 2:1 | ||||
| 13. Ronde | 31.10.2004 | CF Pachuca | - | Santos Laguna | 2:1 | ||||
| 14. Ronde | 03.11.2004 | Santos Laguna | - | Deportivo Toluca | 0:1 | ||||
| 15. Ronde | 07.11.2004 | Veracruz (old) | - | Santos Laguna | 3:2 | |
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| 16. Ronde | 14.11.2004 | Santos Laguna | - | UANL Tigres | 2:1 |  |
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| 17. Ronde | 21.11.2004 | Cruz Azul | - | Santos Laguna | 1:0 |
Mexico