| 2. Ronde | 07.08.2005 | Atlante | - | Santos Laguna | 0:0 | ||||
| 3. Ronde | 14.08.2005 | Santos Laguna | - | UANL Tigres | 1:4 | ||||
| 11. Ronde | 02.10.2005 | CF Monterrey | - | Santos Laguna | 2:2 | ||||
| 13. Ronde | 23.10.2005 | Monarcas Morelia | - | Santos Laguna | 1:0 | ||||
| 16. Ronde | 20.11.2005 | Santos Laguna | - | Deportivo Toluca | 4:1 |  |
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| 17. Ronde | 26.11.2005 | Jaguares Chiapas | - | Santos Laguna | 5:1 |
Mexico