| 1. Ronde | 14.08.2021 | SD Ponferradina | - | AD Alcorcón | 1:0 | ||||
| 2. Ronde | 22.08.2021 | SD Eibar | - | SD Ponferradina | 0:1 | ||||
| 3. Ronde | 28.08.2021 | SD Ponferradina | - | Girona FC | 2:1 | ||||
| 11. Ronde | 21.10.2021 | Real Zaragoza | - | SD Ponferradina | 1:1 | ||||
| 15. Ronde | 06.11.2021 | CD Lugo | - | SD Ponferradina | 1:2 | ||||
| 18. Ronde | 28.11.2021 | UD Ibiza | - | SD Ponferradina | 0:1 | ||||
| 20. Ronde | 12.12.2021 | CD Leganés | - | SD Ponferradina | 1:1 | ||||
| 21. Ronde | 19.12.2021 | SD Ponferradina | - | SD Amorebieta | 1:1 |  |
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| 23. Ronde | 09.01.2022 | SD Ponferradina | - | Real Zaragoza | 0:0 | ||||
| 29. Ronde | 27.02.2022 | AD Alcorcón | - | SD Ponferradina | 2:2 | ||||
| 33. Ronde | 27.03.2022 | CD Mirandés | - | SD Ponferradina | 3:1 | ||||
| 34. Ronde | 03.04.2022 | SD Ponferradina | - | UD Las Palmas | 1:2 | ||||
| 36. Ronde | 17.04.2022 | SD Ponferradina | - | CD Lugo | 3:1 | ||||
| 37. Ronde | 23.04.2022 | CF Fuenlabrada | - | SD Ponferradina | 2:3 | ||||
| 38. Ronde | 01.05.2022 | SD Ponferradina | - | FC Cartagena | 4:2 | ||||
| 39. Ronde | 07.05.2022 | SD Ponferradina | - | Burgos CF | 3:1 | ||||
| 41. Ronde | 21.05.2022 | SD Ponferradina | - | CD Leganés | 0:3 | ||||
| 42. Ronde | 28.05.2022 | SD Amorebieta | - | SD Ponferradina | 1:0 | |
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