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| 05.11.2021 | 21:00 | SD Huesca | - | CD Leganés | 0:2 (0:0) | |
| 06.11.2021 | 16:00 | CD Lugo | - | SD Ponferradina | 1:2 (0:1) | |
| 18:15 | Real Oviedo | - | UD Las Palmas | 1:1 (1:0) | ||
| 18:15 | Real Valladolid | - | CD Mirandés | 3:1 (2:0) | ||
| 21:00 | CF Fuenlabrada | - | SD Eibar | 0:0 (0:0) | ||
| 07.11.2021 | 14:00 | AD Alcorcón | - | SD Amorebieta | 2:2 (0:1) | |
| 16:00 | Real Zaragoza | - | Sporting Gijón | 2:0 (1:0) | ||
| 18:15 | FC Cartagena | - | Málaga CF | 3:1 (1:0) | ||
| 18:15 | UD Almería | - | Burgos CF | 2:0 (1:0) | ||
| 21:00 | Real Sociedad B | - | UD Ibiza | 0:1 (0:0) | ||
| 08.11.2021 | 21:00 | CD Tenerife | - | Girona FC | 2:1 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
UD Almería | 15 | 11 | 1 | 3 | 29:11 | 18 | 34 |
| 2 |
|
SD Eibar | 15 | 8 | 4 | 3 | 20:16 | 4 | 28 |
| 3 |
|
CD Tenerife | 15 | 8 | 3 | 4 | 21:13 | 8 | 27 |
| 4 |
|
UD Las Palmas | 15 | 7 | 6 | 2 | 22:15 | 7 | 27 |
| 5 |
|
SD Ponferradina | 15 | 7 | 5 | 3 | 19:13 | 6 | 26 |
| 6 |
|
Real Valladolid | 15 | 7 | 4 | 4 | 21:17 | 4 | 25 |
| 7 |
|
UD Ibiza | 15 | 5 | 7 | 3 | 18:18 | 0 | 22 |
| 8 |
|
Sporting Gijón | 15 | 6 | 4 | 5 | 16:16 | 0 | 22 |
| 9 |
|
FC Cartagena | 15 | 7 | 1 | 7 | 21:22 | -1 | 22 |
| 10 |
|
Málaga CF | 15 | 5 | 5 | 5 | 14:18 | -4 | 20 |
| 11 |
|
Real Oviedo | 15 | 4 | 8 | 3 | 16:15 | 1 | 20 |
| 12 |
|
Real Zaragoza | 15 | 3 | 10 | 2 | 12:11 | 1 | 19 |
| 13 |
|
CD Mirandés | 15 | 5 | 3 | 7 | 23:26 | -3 | 18 |
| 14 |
|
Girona FC | 15 | 5 | 3 | 7 | 16:18 | -2 | 18 |
| 15 |
|
SD Huesca | 15 | 4 | 5 | 6 | 17:17 | 0 | 17 |
| 16 |
|
CD Lugo | 15 | 3 | 7 | 5 | 17:19 | -2 | 16 |
| 17 |
|
CF Fuenlabrada | 15 | 3 | 7 | 5 | 12:14 | -2 | 16 |
| 18 |
|
Burgos CF | 15 | 4 | 4 | 7 | 13:17 | -4 | 16 |
| 19 |
|
CD Leganés | 15 | 3 | 5 | 7 | 15:19 | -4 | 14 |
| 20 |
|
Real Sociedad B | 15 | 3 | 5 | 7 | 14:18 | -4 | 14 |
| 21 |
|
SD Amorebieta | 15 | 2 | 7 | 6 | 18:22 | -4 | 13 |
| 22 |
|
AD Alcorcón | 15 | 2 | 2 | 11 | 12:31 | -19 | 8 |
| Promotie | |
| Play-offs | |
| Degradatie |
