| 1. Ronde | 18.09.2021 | CF Pachuca [] | - | Deportivo Toluca [] | 5:0 | ||||
| 2. Ronde | 25.09.2021 | Cruz Azul [] | - | CF Pachuca [] | 3:6 | ||||
| 3. Ronde | 02.10.2021 | CF Pachuca [] | - | Puebla FC [] | 4:0 | ||||
| 8. Ronde | 06.11.2021 | CF Pachuca [] | - | CF América [] | 5:3 | ||||
| 9. Ronde | 13.11.2021 | Deportivo Toluca [] | - | CF Pachuca [] | 4:3 |  |
Mexico