| 1. Ronde | 10.01.2021 | CF América | - | Atlético San Luis | 2:1 | ||||
| 2. Ronde | 17.01.2021 | CF Monterrey | - | CF América | 1:0 | ||||
| 3. Ronde | 27.01.2021 | CF América | - | FC Juárez | 2:0 | ||||
| 4. Ronde | 01.02.2021 | Santos Laguna | - | CF América | 1:1 | ||||
| 5. Ronde | 07.02.2021 | CF América | - | Puebla FC | 1:0 | ||||
| 6. Ronde | 14.02.2021 | CF América | - | Gallos Blancos | 2:1 | ||||
| 7. Ronde | 21.02.2021 | Atlas Guadalajara | - | CF América | 3:0 Toeg. |  |
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| 8. Ronde | 28.02.2021 | CF América | - | CF Pachuca | 2:0 | ||||
| 9. Ronde | 04.03.2021 | Club Tijuana | - | CF América | 0:2 | ||||
| 10. Ronde | 07.03.2021 | CF América | - | Club León | 2:1 | ||||
| 11. Ronde | 15.03.2021 | Deportivo Guadalajara | - | CF América | 0:3 | ||||
| 12. Ronde | 20.03.2021 | Mazatlán FC | - | CF América | 0:1 | ||||
| 13. Ronde | 04.04.2021 | CF América | - | Club Necaxa | 2:1 | |
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| 15. Ronde | 18.04.2021 | CF América | - | Cruz Azul | 1:1 |
Uruguay
Spanje