| 2. Ronde | 01.08.2021 | CF América | - | Club Necaxa | 2:1 | ||||
| 3. Ronde | 08.08.2021 | CF América | - | Puebla FC | 2:0 | ||||
| 4. Ronde | 16.08.2021 | Atlas Guadalajara | - | CF América | 0:1 | ||||
| 9. Ronde | 19.09.2021 | Deportivo Toluca | - | CF América | 3:1 |  |
|||
| 12. Ronde | 04.10.2021 | CF América | - | Pumas UNAM | 2:0 | ||||
| 13. Ronde | 17.10.2021 | Atlético San Luis | - | CF América | 0:1 | ||||
| 14. Ronde | 20.10.2021 | CF América | - | Santos Laguna | 2:1 | ||||
| 15. Ronde | 24.10.2021 | CF América | - | UANL Tigres | 1:0 |
Uruguay
Spanje