| 1. Ronde | 26.07.2021 | Club Tijuana [U20] | - | UANL Tigres [U20] | 1:1 |  |
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| 2. Ronde | 31.07.2021 | Club León [U20] | - | Club Tijuana [U20] | 2:1 | ||||
| 4. Ronde | 13.08.2021 | FC Juárez [U20] | - | Club Tijuana [U20] | 1:3 | ||||
| 6. Ronde | 22.08.2021 | CF América [U20] | - | Club Tijuana [U20] | 1:1 | |
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| 15. Ronde | 24.10.2021 | Pumas UNAM [U20] | - | Club Tijuana [U20] | 4:0 | ||||
| 16. Ronde | 28.10.2021 | Atlas Guadalajara [U20] | - | Club Tijuana [U20] | 1:1 | |
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| 17. Ronde | 10.11.2021 | Club Tijuana [U20] | - | CF Pachuca [U20] | 2:1 | |
Mexico