| 1. Ronde | 12.02.2022 | UD Vilafranquense [A-jun] | - | Os Belenenses [A-jun] | 3:1 | ||||
| 2. Ronde | 19.02.2022 | Vitória Setúbal [A-jun] | - | UD Vilafranquense [A-jun] | 2:2 | ||||
| 3. Ronde | 26.02.2022 | União Leiria [A-jun] | - | UD Vilafranquense [A-jun] | 0:0 | ||||
| 4. Ronde | 05.03.2022 | UD Vilafranquense [A-jun] | - | Académica de Coimbra [A-jun] | 1:2 |  |
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| 6. Ronde | 19.03.2022 | UD Vilafranquense [A-jun] | - | Amora FC [A-jun] | 2:1 | |
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| 7. Ronde | 02.04.2022 | SG Sacavenense [A-jun] | - | UD Vilafranquense [A-jun] | 1:1 | ||||
| 8. Ronde | 09.04.2022 | Os Belenenses [A-jun] | - | UD Vilafranquense [A-jun] | 2:1 | ||||
| 9. Ronde | 16.04.2022 | UD Vilafranquense [A-jun] | - | Vitória Setúbal [A-jun] | 2:0 | ||||
| 10. Ronde | 23.04.2022 | UD Vilafranquense [A-jun] | - | União Leiria [A-jun] | 2:1 | ||||
| 11. Ronde | 30.04.2022 | Académica de Coimbra [A-jun] | - | UD Vilafranquense [A-jun] | 1:1 | ||||
| 12. Ronde | 07.05.2022 | UD Vilafranquense [A-jun] | - | CD Nacional [A-jun] | 0:1 | ||||
| 13. Ronde | 14.05.2022 | Amora FC [A-jun] | - | UD Vilafranquense [A-jun] | 2:2 | ||||
| 14. Ronde | 21.05.2022 | UD Vilafranquense [A-jun] | - | SG Sacavenense [A-jun] | 1:1 |
Portugal