| 3. Ronde | 21.08.2021 | UD Vilafranquense [A-jun] | - | SL Benfica [A-jun] | 0:7 | ||||
| 4. Ronde | 28.08.2021 | SL Benfica [A-jun] | - | Académica de Coimbra [A-jun] | 6:1 | ||||
| 6. Ronde | 18.09.2021 | SL Benfica [A-jun] | - | GD Estoril [A-jun] | 4:1 | ||||
| 7. Ronde | 25.09.2021 | Vitória Setúbal [A-jun] | - | SL Benfica [A-jun] | 1:1 | ||||
| 10. Ronde | 23.10.2021 | SL Benfica [A-jun] | - | Amora FC [A-jun] | 7:0 |  |
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| 11. Ronde | 31.10.2021 | CD Nacional [A-jun] | - | SL Benfica [A-jun] | 0:6 | ||||
| 5. Ronde | 03.11.2021 | SG Sacavenense [A-jun] | - | SL Benfica [A-jun] | 2:6 | ||||
| 12. Ronde | 06.11.2021 | SL Benfica [A-jun] | - | União Leiria [A-jun] | 4:1 | ||||
| 14. Ronde | 27.11.2021 | SL Benfica [A-jun] | - | UD Vilafranquense [A-jun] | 8:0 | ||||
| 15. Ronde | 01.12.2021 | Académica de Coimbra [A-jun] | - | SL Benfica [A-jun] | 1:1 | ||||
| 21. Ronde | 22.01.2022 | Amora FC [A-jun] | - | SL Benfica [A-jun] | 0:3 | ||||
| 22. Ronde | 29.01.2022 | SL Benfica [A-jun] | - | CD Nacional [A-jun] | 4:0 |
Guinea-Bissau