| 13. Ronde | 16.10.2021 | Atlético San Luis [U20] | - | CF América [U20] | 1:0 |  |
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| 15. Ronde | 24.10.2021 | Atlético San Luis [U20] | - | Atlas Guadalajara [U20] | 0:2 | ||||
| 16. Ronde | 31.10.2021 | Atlético San Luis [U20] | - | CF Monterrey [U20] | 3:1 | |
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| 5. Ronde | 03.11.2021 | CF Pachuca [U20] | - | Atlético San Luis [U20] | 1:3 |  |
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| 17. Ronde | 07.11.2021 | Santos Laguna [U20] | - | Atlético San Luis [U20] | 2:1 |  |
Mexico