| 1. Ronde | 08.08.2021 | Stade Rennais | - | RC Lens | 1:1 | ||||
| 3. Ronde | 21.08.2021 | AS Monaco | - | RC Lens | 0:2 | ||||
| 4. Ronde | 29.08.2021 | RC Lens | - | FC Lorient | 2:2 | ||||
| 5. Ronde | 12.09.2021 | Girondins Bordeaux | - | RC Lens | 2:3 | ||||
| 6. Ronde | 18.09.2021 | RC Lens | - | Lille OSC | 1:0 | ||||
| 7. Ronde | 22.09.2021 | RC Lens | - | RC Strasbourg | 0:1 | ||||
| 9. Ronde | 01.10.2021 | RC Lens | - | Stade de Reims | 2:0 | ||||
| 11. Ronde | 24.10.2021 | RC Lens | - | FC Metz | 4:1 | ||||
| 13. Ronde | 05.11.2021 | RC Lens | - | ESTAC Troyes | 4:0 | ||||
| 15. Ronde | 26.11.2021 | RC Lens | - | Angers SCO | 2:2 | ||||
| 16. Ronde | 01.12.2021 | Clermont Foot 63 | - | RC Lens | 2:2 | ||||
| 17. Ronde | 04.12.2021 | RC Lens | - | Paris Saint-Germain | 1:1 | ||||
| 18. Ronde | 10.12.2021 | FC Nantes | - | RC Lens | 3:2 | ||||
| 19. Ronde | 22.12.2021 | OGC Nice | - | RC Lens | 2:1 | ||||
| 23. Ronde | 06.02.2022 | FC Lorient | - | RC Lens | 2:0 |  |
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| 32. Ronde | 16.04.2022 | Lille OSC | - | RC Lens | 1:2 |  |
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| 33. Ronde | 20.04.2022 | RC Lens | - | Montpellier HSC | 2:0 | ||||
| 38. Ronde | 21.05.2022 | RC Lens | - | AS Monaco | 2:2 |
Frankrijk