| 1. Ronde | 07.08.2021 | FC Black Stars Basel | - | FC Basel 1893 II | 3:2 |  |
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| 3. Ronde | 21.08.2021 | FC Stade Nyonnais | - | FC Basel 1893 II | 4:5 | ||||
| 4. Ronde | 28.08.2021 | FC Basel 1893 II | - | AC Bellinzona | 2:1 | ||||
| 5. Ronde | 04.09.2021 | FC Basel 1893 II | - | BSC Young Boys II | 5:2 | ||||
| 6. Ronde | 11.09.2021 | FC Basel 1893 II | - | FC Chiasso | 3:3 | ||||
| 7. Ronde | 22.09.2021 | FC Biel/Bienne | - | FC Basel 1893 II | 1:1 | |
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| 8. Ronde | 25.09.2021 | FC Rapperswil-Jona | - | FC Basel 1893 II | 2:3 | |
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| 9. Ronde | 02.10.2021 | FC Basel 1893 II | - | FC Sion II | 6:2 | ||||
| 10. Ronde | 09.10.2021 | Etoile Carouge FC | - | FC Basel 1893 II | 2:1 | ||||
| 11. Ronde | 16.10.2021 | FC Basel 1893 II | - | FC Zürich II | 1:1 | ||||
| 13. Ronde | 30.10.2021 | FC Basel 1893 II | - | SC Brühl | 1:3 | ||||
| 14. Ronde | 06.11.2021 | SC YF/Juventus Zürich | - | FC Basel 1893 II | 6:0 | ||||
| 15. Ronde | 13.11.2021 | FC Basel 1893 II | - | SC Cham | 3:4 | ||||
| 17. Ronde | 27.11.2021 | FC Bavois | - | FC Basel 1893 II | 2:0 | ||||
| 18. Ronde | 04.12.2021 | FC Basel 1893 II | - | FC Stade Nyonnais | 0:6 | |
Zwitserland