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| 14.02.2022 | 19:30 | Royal Excel Mouscron II | - | KAS Eupen II | 2:0 | |
| 19:30 | KV Kortrijk II | - | Union St. Gilloise II | 1:1 | ||
| 20:00 | SK Deinze II | - | SK Beveren II | 1:3 | ||
| 20:00 | KVC Westerlo II | - | Lommel SK II | 3:2 | ||
| 20:00 | RFC Seraing II | - | KV Oostende II | 1:0 | ||
| 20:00 | K Beerschot VA II | - | RWDM Brussels FC II | 1:0 | ||
| 20:00 | Lierse Kempenzonen II | - | Excelsior Virton II | 1:3 |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
K Beerschot VA II | 19 | 13 | 4 | 2 | 47:18 | 29 | 43 |
| 2 |
|
KAS Eupen II | 19 | 14 | 1 | 4 | 46:23 | 23 | 43 |
| 3 |
|
KV Oostende II | 19 | 9 | 7 | 3 | 46:25 | 21 | 34 |
| 4 |
|
Excelsior Virton II | 19 | 10 | 2 | 7 | 45:47 | -2 | 32 |
| 5 |
|
Royal Excel Mouscron II | 19 | 9 | 4 | 6 | 38:21 | 17 | 31 |
| 6 |
|
SK Beveren II | 19 | 10 | 1 | 8 | 35:21 | 14 | 31 |
| 7 |
|
Union St. Gilloise II | 19 | 8 | 4 | 7 | 26:20 | 6 | 28 |
| 8 |
|
RWDM Brussels FC II | 19 | 8 | 2 | 9 | 41:41 | 0 | 26 |
| 9 |
|
KVC Westerlo II | 19 | 8 | 2 | 9 | 32:34 | -2 | 26 |
| 10 |
|
RFC Seraing II | 19 | 7 | 1 | 11 | 27:36 | -9 | 22 |
| 11 |
|
Lierse Kempenzonen II | 19 | 6 | 4 | 9 | 24:45 | -21 | 22 |
| 12 |
|
SK Deinze II | 19 | 5 | 3 | 11 | 21:43 | -22 | 18 |
| 13 |
|
Lommel SK II | 19 | 3 | 3 | 13 | 18:46 | -28 | 12 |
| 14 |
|
KV Kortrijk II | 19 | 1 | 6 | 12 | 21:47 | -26 | 9 |
| Promotie |
