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| 13.09.2021 | 19:30 | Royal Excel Mouscron II | - | SK Beveren II | 1:0 | |
| 19:30 | KV Oostende II | - | RWDM Brussels FC II | 4:3 | ||
| 19:30 | KV Kortrijk II | - | SK Deinze II | 0:1 | ||
| 20:00 | Lommel SK II | - | Union St. Gilloise II | 2:0 | ||
| 20:00 | KVC Westerlo II | - | KAS Eupen II | 2:1 | ||
| 20:00 | Lierse Kempenzonen II | - | RFC Seraing II | 2:1 | ||
| 15.11.2021 | 20:00 | K Beerschot VA II | - | Excelsior Virton II | 1:1 |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KV Oostende II | 3 | 2 | 1 | 0 | 13:4 | 9 | 7 |
| 2 |
|
SK Beveren II | 3 | 2 | 0 | 1 | 7:1 | 6 | 6 |
| 3 |
|
RFC Seraing II | 3 | 2 | 0 | 1 | 4:2 | 2 | 6 |
| 4 |
|
Royal Excel Mouscron II | 3 | 2 | 0 | 1 | 3:1 | 2 | 6 |
| 5 |
|
SK Deinze II | 3 | 2 | 0 | 1 | 2:1 | 1 | 6 |
| 6 |
|
Lierse Kempenzonen II | 3 | 2 | 0 | 1 | 3:7 | -4 | 6 |
| 7 |
|
KAS Eupen II | 3 | 1 | 1 | 1 | 6:5 | 1 | 4 |
| 8 |
|
Union St. Gilloise II | 3 | 1 | 1 | 1 | 3:4 | -1 | 4 |
| 9 |
|
K Beerschot VA II | 3 | 1 | 1 | 1 | 2:3 | -1 | 4 |
| 10 |
|
Excelsior Virton II | 3 | 1 | 1 | 1 | 4:11 | -7 | 4 |
| 11 |
|
Lommel SK II | 3 | 1 | 0 | 2 | 5:6 | -1 | 3 |
| 12 |
|
KVC Westerlo II | 3 | 1 | 0 | 2 | 2:3 | -1 | 3 |
| 13 |
|
RWDM Brussels FC II | 3 | 0 | 1 | 2 | 6:8 | -2 | 1 |
| 14 |
|
KV Kortrijk II | 3 | 0 | 0 | 3 | 0:4 | -4 | 0 |
| Promotie |
