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| 18.09.2021 | 14:00 | Standard Liège | - | Cercle Brugge | 5:0 (0:0) | |
| 14:00 | Club Brugge KV | - | Sporting Charleroi | 1:0 (0:0) | ||
| 14:15 | KVC Westerlo | - | KRC Genk | 2:6 (0:0) | ||
| 14:30 | Sint-Truidense VV | - | SV Zulte Waregem | 1:1 (0:0) | ||
| 15:00 | Oud-Heverlee Leuven | - | Royal Antwerp FC | 0:0 (0:0) | ||
| 15:00 | RSC Anderlecht | - | KAA Gent | 5:2 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KRC Genk | 5 | 4 | 1 | 0 | 17:7 | 10 | 13 |
| 2 |
|
Club Brugge KV | 5 | 3 | 2 | 0 | 13:3 | 10 | 11 |
| 3 |
|
SV Zulte Waregem | 5 | 3 | 2 | 0 | 9:5 | 4 | 11 |
| 4 |
|
RSC Anderlecht | 4 | 3 | 1 | 0 | 13:6 | 7 | 10 |
| 5 |
|
KAA Gent | 5 | 3 | 0 | 2 | 13:10 | 3 | 9 |
| 6 |
|
Standard Liège | 5 | 2 | 0 | 3 | 9:6 | 3 | 6 |
| 7 |
|
Sporting Charleroi | 5 | 1 | 2 | 2 | 7:10 | -3 | 5 |
| 8 |
|
Sint-Truidense VV | 5 | 0 | 4 | 1 | 6:8 | -2 | 4 |
| 9 |
|
Royal Antwerp FC | 4 | 1 | 1 | 2 | 4:6 | -2 | 4 |
| 10 |
|
KV Mechelen | 4 | 1 | 1 | 2 | 7:14 | -7 | 4 |
| 11 |
|
Oud-Heverlee Leuven | 4 | 1 | 1 | 2 | 5:12 | -7 | 4 |
| 12 |
|
KVC Westerlo | 4 | 0 | 1 | 3 | 7:13 | -6 | 1 |
| 13 |
|
Cercle Brugge | 5 | 0 | 0 | 5 | 6:16 | -10 | 0 |
